le cell sentence in Hindi
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- The first evidence for antinuclear antibodies arose in 1948 when Hargraves, Richmond and Morton discovered the LE cell.
- Because of this, the LE cell test is now performed only rarely and is mostly of historical significance.
- The discovery of the LE cell led to further research and this resulted in more definitive tests for lupus.
- Classically, the LE cell is analyzed microscopically, but it is also possible to investigate this phenomenon by flow cytometry.
- An "'LE cell "'is a neutrophil or macrophage that has phagocytized ( engulfed ) the denatured nuclear material of another cell.
- The LE cell, it was determined, was a part of an anti-nuclear antibody ( ANA ) reaction; the body produces antibodies against its own tissue.
- A major breakthrough was made in 1948 with the discovery of the LE cell ( the lupus erythematosus cell a misnomer, as it occurs with other diseases as well ).
- The material has a positive Feulgen stain reaction, which is typical of DNA . The material may be extracellular or may be ingested by leukocytes, which are then known as LE cells.
- The LE cell was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves ( 1903 & ndash; 1982 ), a Physician and Practicing Histologist at the Mayo Clinic " et al ."
- Noting that the invading nucleus was coated with antibody that allowed it to be ingested by a phagocytic or scavenger cell, they named the antibody that causes one cell to ingest another the LE factor and the two nuclei cell result in the LE cell.
- The lupus erythematosus ( LE ) cell test was commonly used for diagnosis, but it is no longer used because the LE cells are only found in 50 75 % of SLE cases, and they are also found in some people with rheumatoid arthritis, scleroderma, and drug sensitivities.
- Building on the knowledge that those with SLE had auto-antibodies that would attach themselves to the nuclei of normal cells, causing the immune system to send white blood cells to fight off these " invaders ", a test was developed to look for the anti-nuclear antibody ( ANA ) rather than the LE cell specifically.
- This discovery led to one of the first definitive tests for lupus since LE cells are found in approximately 60 % of all people diagnosed with lupus . " ( Note : The LE cell test is rarely performed as a definitive lupus test today as LE cells do not always occur in people with SLE and can occur in individuals with other autoimmune diseases.
- This discovery led to one of the first definitive tests for lupus since LE cells are found in approximately 60 % of all people diagnosed with lupus . " ( Note : The LE cell test is rarely performed as a definitive lupus test today as LE cells do not always occur in people with SLE and can occur in individuals with other autoimmune diseases.
- This discovery led to one of the first definitive tests for lupus since LE cells are found in approximately 60 % of all people diagnosed with lupus . " ( Note : The LE cell test is rarely performed as a definitive lupus test today as LE cells do not always occur in people with SLE and can occur in individuals with other autoimmune diseases.
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